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Understanding ‘Baby Brain’: Key Insights Into How Pregnancy Changes the Brain

Understanding ‘Baby Brain’: Key Insights Into How Pregnancy Changes the Brain
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  • PublishedMay 24, 2025

The term “baby brain” is often used to describe the forgetfulness or mental fog many women experience during pregnancy, but recent scientific research confirms that these changes reflect real and complex transformations in the brain, CNN reports.

The brain is not a static organ; it continuously adapts throughout life in a process called neuroplasticity. Researchers have found that the female brain undergoes significant remodeling during three key life stages: puberty, pregnancy, and perimenopause. These periods, sometimes trivialized in popular culture, involve substantial hormonal fluctuations that influence brain function and structure.

Laura Pritschet, a cognitive neuroscientist at the University of Pennsylvania, studies how hormones like estrogen and progesterone affect the brain’s organization. Her recent work, including detailed brain scans and blood tests over the course of pregnancy and postpartum, has shed light on the brain’s remarkable adaptability during this time.

One notable finding is a decrease of about 3 to 5 percent in gray matter volume across much of the brain during pregnancy. Gray matter contains the neurons responsible for processing and cognition. Alongside this reduction, increases in white matter—tissue that connects different brain regions—and enlargement of the brain’s ventricles were observed. These changes appear to be part of a carefully coordinated process, possibly linked to increased blood flow and swelling during pregnancy, as well as preparation for the cognitive demands of parenting.

Importantly, the decrease in gray matter volume does not imply damage. Instead, researchers suggest it reflects a “fine-tuning” or pruning of brain circuits, much like what occurs during adolescence, which may make certain brain networks more efficient. Some areas of gray matter show partial recovery postpartum, while others remain altered for longer periods.

Pritschet emphasizes that pregnancy is a critical period of brain development occurring well into adulthood and is part of the broader life-long neuroplasticity seen in humans. The changes seen in the brain during pregnancy may also have implications for understanding postpartum mental health conditions such as depression, as well as behavioral differences in parenting.

In summary, here are three key points about what happens to the brain during pregnancy:

  1. The Brain Undergoes Significant Change: Pregnancy triggers widespread physiological and neurological transformations, reflecting the body’s adaptation to motherhood.

  2. Gray Matter Reductions Are Expected and Possibly Beneficial: Decreases in gray matter volume are part of a natural “fine-tuning” process rather than a sign of harm, supporting new cognitive and behavioral demands.

  3. These Changes May Affect Future Health and Behavior: Understanding these brain adaptations could provide insight into mental health risks and parental behaviors after childbirth, as well as brain function over the lifespan.

Joe Yans

Joe Yans is a 25-year-old journalist and interviewer based in Cheyenne, Wyoming. As a local news correspondent and an opinion section interviewer for Wyoming Star, Joe has covered a wide range of critical topics, including the Israel-Palestine war, the Russia-Ukraine conflict, the 2024 U.S. presidential election, and the 2025 LA wildfires. Beyond reporting, Joe has conducted in-depth interviews with prominent scholars from top US and international universities, bringing expert perspectives to complex global and domestic issues.